An informative overview of the components in our beloved hemp plant.
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Here is version 1 (v1) and of course we are already working and researching for the next version.
Current version: v1

Download (PDF): Cannabinoide, Terpene und Flavonoide - wissenswertes_v1

Structure and connections of cannabinoids, cannabinoid acids, Varine and terpens/terpenoids.
Cannabinoids_Acids_Terpens_ODM_EN.pdf

Dronabinol

Autoren: Prof. Dr. med. Peter Altmeyer, Dr. med. S. Leah Schröder-Bergmann
Zuletzt aktualisiert am: 16.05.2022

Synonym(e)
CAS-Nummer:1972-08-3; Delta-9-THC

definition
Dronabinol is an orally available cannabinoid agonist, an isomer of tetrahydrocannabinol (THC), the main and most active isomer of the Cannabis sativa L. plant, with potential antiemetic, analgesic and appetite stimulant effects. Once administered, dronabinol, also known as “Delta-9-THC,” targets and binds to cannabinoid receptors (CB1/CB2) in the central nervous system (CNS).

Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent vomiting. In addition, this drug induces analgesia. Dronabinol has relatively poor bioavailability; the synthetic THC analogue nabilone, on the other hand, has better bioavailability.

classification
In the cannabis plant, tetrahydrocannabinol is predominantly present as THC acid. Cannabigerolic acid is formed by enzymatic condensation of the two precursors geranyl pyrophosphate and olivetolic acid, which is then enzymatically rearranged into tetrahydrocannabinolic acid. With heat and UV radiation, the acid decarboxylates to form THC.

There are four stereoisomers of delta-9-tetrahydrocannabinol:

(–)-Δ9-trans-Tetrahydrocannabinol (Dronabiol)
(+)-Δ9-trans-Tetrahydrocannabinol (THC)
(–)-Δ9-cis-tetrahydrocannabinol (no psychoactivity)
(+)-Δ9-cis-tetrahydrocannabinol (no psychoactivity)
Dronabinol is the most psychoactive isomer. It is 6 to 100 times more potent than (+)-Δ9-trans-THC (THC). The cis-forms have no psychoactive effect, there are different statements about their natural occurrence.

pharmacokinetics
Dronabinol is excreted hepatogenic and nephrogenic. Urine levels can be used as a marker to measure exposure to certain preparations containing parts of the cannabis plant, such as B. Marijuana to determine.

indication
Dronabinol is prescribed as an oral cannabinoid agonist to treat nausea and vomiting associated with chemotherapy, and anorexia and weight loss in HIV/AIDS patients. But dronabinol can also be prescribed for all other areas of application within the framework of the Cannabis Act (see below Cannabis as a drug prescription).

Preparates
cbd-Loges® Cannabis-Öl; Dronabinol Spectrum Therapeutics®